Many thanks to dentist Dr. Dave Warwick, Hanna AB, for providing an update and bibliography on the Research on the health effects of mercury fillings.
Scroll past the indented paragraphs (which are for newcomers), straight to heading From: dentist Dr. David Warwick, Hanna AB.
The less spirited would have sighed and gone away
The intrepids keep on singing and smiling
A warning to the Harmful Status Quo
While you get high in the evening
Others may be turned on by
Un-doing the harm
And culprits in the doing
I see where we have on this blog more than 80 postings collected through the years, on mercury poisoning from dental amalgams (under the category “Health”). Some are about the UN Treaty to get rid of products containing mercury (we are poisoning ourselves and the environment in which we have to live. Mercury travels.). Dave participated in, for example,
(the posting contains links to more material)
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REQUEST sent to Dave, Aug 16, 2016:
Why I called you
QUESTION (perennial): is there information that should be shared, would be helpful, in event that law suit over mercury fillings is pursued?
I don’t want to pre-judge the likelihood that a suit would ever be launched in Canada; it’s come up again.
Has anything changed? Is the liability issue, for Government Health Depts and for the Dental Industry so huge that liability will never be acknowledged? (which would be why all the solid information that can be brought to bear is not heard or acted upon. Can they not understand that they just have to stop putting mercury into people’s mouths? and they have to re-train to know how to remove mercury fillings with the least damage possible to themselves, their staff and the patients? )
How much is explained by: 2011-06-28 Canada’s chief dentist works for the amalgam industry. No wonder mercury fillings receive an exemption! ?
A woman Susan my age from Vancouver who has MS is incensed about the mercury fillings and vaccinations. Has done a lot of research.
She talked with a Vanc Law Firm:
The law firm I emailed to last week phoned today and stated that she would speak with her co-workers as to joining a class action lawsuit or whatever and will get back to me later in the week. That sounds like a good thing as I have no other thoughts on how to proceed. A class action lawsuit will send a definite message to our mercury-loving government officials who don’t care if we live or die that they should have never allowed amalgam fillings to be installed in peoples’ teeth!!!!! when they absolutely knew better.
She is conversant with Dr Vimy’s work. Grant reminded me: Vimy did the “smoking teeth” video (click the link, Smoking Teeth is the first in this list of videos). There’s his research using insertion of amalgam in sheep.
The most recent I could find online re Vimy is 2011 (he is retired), a short CBC newscast https://www.youtube.com/watch?v=HavLXo_0Xpk He is well-spoken, good interview. (end)
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the route that will bear actual results ?
– keep sharing information, grow the number of people who are informed.
– Simultaneously use the UN Treaty on Mercury to bring pressure on the dental colleges to stop the insertion of MORE mercury fillings.
– Conversations with the institutions that certify Dental Hygienists & Assistants to emphasize the health risks to these women
– Which leaves individual older dentists who refuse to change their ways as culprits.
– Dental Colleges (some or all?) run clinics in which dental students develop their craft. People who can’t afford to pay a dentist qualify as “the patients”. A young female friend who is a law student went for a filling last year. She didn’t know about mercury fillings. That’s what they filled her tooth with. (The College has received information about the UN Treaty, etc.. Information makes no difference. They dismiss it as crazy people who don’t know the science.) A fellow who came to the Mercury Jamboree is First Nations. The Clinic at the Dental College serves many First Nations people. They all get mercury fillings.
Anyhow – – be persistent and patient. Others have to assume responsibility, too. Perhaps there will be yet more attention paid to the effects of the mercury poisoning on brain functioning:
Huge numbers of baby boomers have had mercury fillings off-gassing in their bodies for decades now. They have added body burden from vaccinations that use ethyl mercury as a preservative. Sixty years of Mercury going to the brain . . . it’s not as if the evidence isn’t there, if you want to find it.
Our immune systems are different, we have different strengths and weaknesses in our immune capabilities. Poisoning by mercury, or other toxics, does not manifest with the same symptoms in everyone. The symptoms (the “disease”) will be different depending on factors like previous exposures, inter-generational damaged DNA, previous injuries, unknowables (many poisons are invisible – think carbon monoxide, think chemicals). But enough! … except
Never mind the mercury that pregnant and breast-feeding baby-boomer-women transmitted to their offspring, who were then given more doses of mercury through vaccinations that definitely contained thimerasol (mercury) as a preservative.
None of this is new – – it’s the lead in gasoline, mercury in paint, cancer in tobacco, Erin Brockavitch, no-we’re-not-torturing-people stories all over again.
The effects of mercury on brain, one small part: we need to re-contact these people with Dave’s update: 2012-07-07 Letter to Health Insurance (mental illness claims approach 50%): stop mercury fillings, reduce mental illness claims.
From: dentist Dr. David Warwick, Hanna AB
The liability issue still comes down to what the scientific evidence shows… up until 2012 one could conclude that the evidence is inconclusive……The studies by Woods et.al. throughout the last few years on genetic susceptibility may have changed this. There are 4 studies that he has published which indicate genetically susceptible sub populations show toxicity to the levels of mercury given off by amalgam. This study does a nice job of summarizing this http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905169/
As well, I am working with a few other folks to publish a paper that further explores susceptible groups to mercury. Our first attempt at publishing was turned down so we are rewriting as we speak… I can’t give you any of the text for the new paper, but the bibliography to date is copied below…
there are two other strategic prongs to discontinuing the use of amalgam. That is the environmental and the occupational issues. The other study we are working on deals with unrealized mercury exposure caused by amalgam particulate. The first submission was denied because of a lack of numbers… so we are working to increase our “n”s and hope to resubmit in October.
As far as question 2, the Health agencies such as Health Canada use earlier studies that use the same data that Woods used in his recent studies to prove “safety”. Nobody has challenged them on this yet.
On the occupational side of things, Alberta Occupational Health and Safety recommended discontinuing amalgam in 2011 ( https://work.alberta.ca/documents/OHS-WSA-handbook-dental-workers.pdf page 23), so they have their butts covered but nobody was listening or wanted to listen.
Environment Canada is a pawn to Health Canada and has no balls. It’s pretty much the same in the states with their three related government organizations.
By the way, one of the fellows I talked to from Health Canada, Phillip Neufeld, stated that the achilles heal of amalgam is the occupational issues. Not that they cannot be overcome, but that the general practice of placing and removing amalgams generally represents an unacceptable level of exposure.
This is a provincial jurisdiction that would involve the dental colleges, the dental assistant and dental hygienist associations and the provincial occupational safety folks. Every province is different, however the key is to rock one, then the others will topple. I hope that the study I am working will increase the conversation regarding occupational and patient safety.
BIBLIOGRAPHY
Weiner JA, Nylander M, Berglund F. Does mercury from amalgam restorations constitute a health hazard? Sci Total Environ. 1990 Dec 1;99(1-2):1-22.
Faggion CM Jr. Is the evidence supporting dental procedures strong? A survey of Cochrane systematic reviews in oral health. J Evid Based Dent Pract. 2012 Sep;12(3):131-134.e14. doi:10.1016/j.jebdp.2012.05.003.
Vähänikkilä H, Tjäderhane L, Nieminen P. The statistical reporting quality of articles published in 2010 in five dental journals. Acta Odontol Scand. 2015 Jan;73(1):76-80. doi: 10.3109/00016357.2014.954612. Epub 2014 Nov 6.
Stegenga J1. Is meta-analysis the platinum standard of evidence? Stud Hist Philos Biol Biomed Sci. 2011 Dec;42(4):497-507. doi: 10.1016/j.shpsc.2011.07.003.
Woods JS, Heyer NJ, Echeverria D, Russo JE, Martin MD, Bernardo MF, Luis HS, Vaz L, Farina FM, Modification of Neurobehavioral effects of Mercury by genetic polymorphism of coproporphyrinogen oxidase in children Neurotoxicol Teratol. 2012 Sep; 34(5): 513–521.
Health Canada. The Safety of Dental Amalgam. 1996. http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/md-im/dent_amalgam-eng.pdf
Berlin M. “Mercury in Dental Materials—an updated risk analysis in environmental medical terms.” An Overview of Scientific Literature published in 1997 to 2002. (The Dental Material Commission, Sweden).
SNC-Lavalin Environment. “Mercury exposure and risks from dental amalgam, part 1: Updating exposure, reexamining reference exposure levels, and critically evaluating recent studies.” Final Report to the International Academy of Oral Medicine and Toxicology. Ref: 10738. (November 8, 2010). Available online at http://www.iaomt.org/articles
Richardson GM, Mercury Exposure and Risks from Dental Amalgam in Canada: The Canadian Health Measures Survey 2007-2009 Human and Ecological Risk Assessment Nov. 2012
Basu N, Goodrich JM, Head J, Ecogenetics of Mercury:From Genetic Polymorphisms and Epigenetics to Risk Assessment and Decision-Making, Environ Toxicol Chem 2014; 33:1248–1258.
Basu N, Goodrich JM, Head J, Ecogenetics of Mercury:From Genetic Polymorphisms and Epigenetics to Risk Assessment and Decision-Making, Environ Toxicol Chem 2014; 33:1248–1258.
Koller VJ1, Fürhacker M, Nersesyan A, Mišík M, Eisenbauer M, Knasmueller S. Cytotoxic and DNA-damaging properties of glyphosate and Roundup in human-derived buccal epithelial cells. Arch Toxicol. 2012 May;86(5):805-13. doi: 10.1007/s00204-012-0804-8. Epub 2012 Feb 14.
Bøhna T, Cuhraa M, Traavika T, Sandenic M, Fagand J, Primiceriob R. Compositional differences in soybeans on the market: Glyphosate accumulates in Roundup Ready GM soybeans., Food Chemistry Volume 153, 15 June 2014, Pages 207–215
Krüger M, Schledorn P, Schrödl W, Hoppe H, Lutz W, Shehata A. Detection of Glyphosate Residues in Animals and Humans. J Environ Anal Toxicol 2014, 4:2
http://dx.doi.org/10.4172/2161-0525.1000210
Kwiatkowska M, Huras B, Bukowska B. The effect of metabolites and impurities of glyphosate on human erythrocytes (in vitro). Pestic Biochem Physiol. 2014 Feb;109:34-43. doi: 10.1016/j.pestbp.2014.01.003. Epub 2014 Jan 25.
Samsel A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases Entropy 2013, 15(4), 1416-1463; doi:10.3390/e15041416
Woods JS, Heyer NJ, Echeverria D, Russo JE, Martin MD, Bernardo MF, Luis HS, Vaz L, Farina FM, Modification of Neurobehavioral effects of Mercury by genetic polymorphism of coproporphyrinogen oxidase in children Neurotoxicol Teratol. 2012 Sep; 34(5): 513–521.
Li, T Coproporphyrinogen oxidase (CPOX) polymorphism in human mercury neurotoxicity. University of Washington, 2009, 98 pages; 3377304
Woods JS, Heyer NJ, Russo JE, Martin MD, Pillai PB, Farin FM Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children. Neurotoxicol Teratol. 2013 Sep-Oct; 0: 36–44.
Woods JS, Heyer NJ, Russo JE, Martin MD, Pillai PB, Farin FM Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children. Neurotoxicol Teratol. 2013 Sep-Oct; 0: 36–44.
Woods JS, Heyer NJ, Russo JE, Martin MD, Pillai PB, Bammler TK, Farin FM Genetic Polymorphisms of catechol-o-methyltransferase modify the neurobehavioral effects of mercury in children. Journal of Toxicology and Environmental Health, Part A, 77:293–312, 2014
Woods JS, Heyer NJ, Russo JE, Martin MD, Farin FM Genetic polymorphisms affecting susceptibility to mercury neurotoxicity in children: Summary findings from the Casa Pia Children’s Amalgam Clinical Trial NeuroToxicology 44 (2014) 288–302 30 July 2014
DeRouen TA1, Martin MD, Leroux BG, Townes BD, Woods JS, Leitão J, Castro-Caldas A, Luis H, Bernardo M, Rosenbaum G, Martins IP Neurobehavioral effects of dental amalgam in children: a randomized clinical trial. JAMA. 2006 Apr 19;295(15):1784-92.
Homme KG, Kern JK, Haley BE, Geier DA, King PG, Sykes LK, Geier MR. New science challenges old notion that mercury dental amalgam is safe Biometals (2014) 27:19–24 DOI 10.1007/s10534-013-9700-9
Wang Y1, Goodrich JM, Gillespie B, Werner R, Basu N, Franzblau A.
An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels Environ Health Perspect. 2012 Apr;120(4):530-4.
Echeverria D, Woods JS, Heyer NJ, Martin MD, Rohlman DS, Farin FM, Li T, The Association Between Serotonisn Transporter Gene Promotor Polymorphism (5-Httlpr) And Elemental Mercury Exposure On Mood And Behavior In Humans J Toxicol Environ Health A. 2010 Jan; 73(15): 1003–1020. doi: 10.1080/15287390903566591
Gundacker C1, Gencik M, Hengstschläger M. The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead. Mutat Res. 2010 Oct;705(2):130-40. doi: 10.1016/j.mrrev.2010.06.003. Epub 2010 Jun 30.
Gundacker C1, Wittmann KJ, Kukuckova M, Komarnicki G, Hikkel I, Gencik M. Genetic background of lead and mercury metabolism in a group of medical students in Austria. Environ Res. 2009 Aug;109(6):786-96. doi: 10.1016/j.envres.2009.05.003. Epub 2009 Jun 9.
Ekstrand J1, Nielsen JB, Havarinasab S, Zalups RK, Söderkvist P, Hultman P. Mercury toxicokinetics–dependency on strain and gender. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):283-91. doi: 10.1016/j.taap.2009.08.026. Epub 2009 Sep 2.
Schubert J, Riley EJ, Tyler SA. Combined effects in Toxicology-A Rapid Systemic Testing Procedure: Cadmium, Mercury, and Lead. Journal of Toxicology and Environmental Health. 4 763-776 1978
Chu KW, Chow KL. Synergistic toxicity of multiple heavy metals is revealed by a biological assay using a nematode and its transgenic derivative Aquatic Toxicology 61 (2002) 53–64
Laks D. Environmental Mercury Exposure and Risk of Autism. Safe Minds, 2008 available at http://www.safeminds.org/wp-content/uploads/2013/04/SM-Env-Mercury-Exposure-and-Risk-of-Autism.pdf
ATSDR. Toxicological Profile for Manganese. Available at http://www.atsdr.cdc.gov/toxprofiles/tp151-c3.pdf
Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease Toxicology 283 (2011) 65–87
Basu N1, Goodrich JM, Head J. Ecogenetics of mercury: from genetic polymorphisms and epigenetics to risk assessment and decision-making. Environ Toxicol Chem. 2014 Jun;33(6):1248-58. doi: 10.1002/etc.2375. Epub 2014 Apr 25.
Onishchenko N1, Karpova N, Sabri F, Castrén E, Ceccatelli S. J Neurochem. Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. 2008 Aug;106(3):1378-87. doi: 10.1111/j.1471-4159.2008.05484.x. Epub 2008 May 15.
Bakulski KM, Lee H, Feinberg JI, Wells EM, Brown S, Herbstman JB, Witter FR, Halden RU, Caldwell K, Mortensen ME, Jaffe AE, Moye J Jr, Caulfield LE, Pan Y, Goldman LR, Feinberg AP, Fallin MD. Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns. Int J Epidemiol. 2015 Aug;44(4):1249-62. doi: 10.1093/ije/dyv032. Epub 2015 Apr 22.
Cardenas A1, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero. Epigenetics. 2015;10(6):508-15. doi: 10.1080/15592294.2015.1046026. Epub 2015 Apr 29.
Stephan Bose-O’Reilly, MD, MPH,a Kathleen M. McCarty, ScD, MPH,b Nadine Steckling, BSc,a and Beate Lettmeier, PhDa Mercury Exposure and Children’s Health Curr Probl Pediatr Adolesc Health Care. 2010 Sep; 40(8): 186–215. doi: 10.1016/j.cppeds.2010.07.002
ATSDR. Toxicological Profile for Mercury. available at http://www.atsdr.cdc.gov/toxprofiles/tp46-c2.pdf